A POWERFUL RESEARCH AND
DEVELOPMENT ENGINE
Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.
Interact with the Regeneron Pipeline
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CEMIPLIMAB*
PD-1 Antibody Cancer -
REGN3767
LAG-3 Antibody Solid tumors, advanced hematologic malignancies -
REGN1979
CD20 X CD3 Antibody B-cell malignancies -
REGN4018*
MUC16 X CD3 Antibody Platinum-resistant ovarian cancer -
REGN5458*
BCMA X CD3 Antibody Multiple myeloma -
REGN5459*
BCMA X CD3 Antibody Multiple myeloma -
REGN5678
PSMA X CD28 Antibody Prostate cancer -
REGN5093
MET X MET Antibody MET-altered advanced non-small cell lung cancer (NSCLC) -
REGN5713-5714-5715
Bet v 1 Antibodies Birch Allergy -
REGN-COV2
SARS-CoV-2 Virus Multi-Antibody Therapy Multi-dose Phase 1 safety study in healthy volunteers
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CEMIPLIMAB*
PD-1 Antibody Basal cell carcinoma (BCC), metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), neoadjuvant CSCC -
AFLIBERCEPT
VEGF-Trap High-dose (8mg) for wet age-related macular degeneration (AMD) -
REGN1979
CD20 X CD3 Antibody B-cell non-Hodgkin lymphoma -
SARILUMAB*
IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis -
DUPILUMAB*
IL-4R Antibody Peanut allergy -
REGN1908-1909
Fel d 1 Multi-Antibody Therapy Cat allergy -
REGN3500*
IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD) -
REGN-COV2
SARS-CoV-2 Virus Multi-Antibody Therapy Treatment for hospitalized and non-hospitalized patients with COVID-19 -
EVINACUMAB
ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia -
POZELIMAB
C5 Antibody Paroxysmal nocturnal hemoglobinuria, CD-55 deficient protein-losing enteropathy -
REGN4461
LEPR Agonist Antibody Generalized lipodystrophy -
GARETOSMAB
Activin-A Antibody Fibrodysplasia Ossificans Progressiva (FOP) -
REGN5069
GFRα3 Antibody Osteoarthritis pain of the knee
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AFLIBERCEPT
VEGF-Trap Retinopathy of prematurity (ROP), high-dose formulation (8mg) for wet age-related macular degeneration (AMD) and diabetic macular edema (DME) -
CEMIPLIMAB*
PD-1 Antibody non-small cell lung cancer (NSCLC), cervical cancer, adjuvant cutaneous squamous cell carcinoma (CSCC) -
DUPILUMAB*
IL-4R Antibody Atopic dermatitis in pediatric patients 6 mo.–11 y.o., asthma in pediatric patients 6-11 y.o., eosinophilic esophagitis?in patients 6 and older, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, prurigo nodularis, chronic spontaneous urticaria,?allergic bronchopulmonary aspergillosis -
REGN-COV2
SARS-CoV-2 Virus Multi-Antibody Therapy Prevention of COVID-19 in household contacts of diagnosed patients -
SARILUMAB*
IL-6R Antibody Ex-U.S. study in hospitalized critical COVID-19 patients -
REGN-EB3
Ebola Multi-Antibody Therapy Ebola virus infection -
ALIROCUMAB*
PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatric patients, heterozygous familial hypercholesterolemia (HeFH) in pediatric patients -
EVINACUMAB
ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH) -
FASINUMAB?
NGF Antibody Osteoarthritis pain of the knee or hip
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* In collaboration with Sanofi
? In collaboration with Teva and Mitsubishi Tanabe
This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.